In recent years, a number of studies have shown that prenatal exposure to sodium valproate (the active ingredient in epilepsy drugs Depacon, Depakene, and Depakote) is linked to increased risk for birth defects. Here, I’ll summarize one
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1992 – Japan finds Depakote, Depakene, Depacon associated with higher birth defect rate
By Jared Fink
Titled “Malformation in infants of mothers with epilepsy receiving antiepileptic drugs.”, a piece of Japanese medical research by S. Kaneko et al. published in April, 1992 helps show just how long it has been known that prenatal exposure…
Finnish Research Shows: Depakote Linked to Birth Defects
By Jared Fink
In May, 2013, a Finnish team of medical researchers led by M. Aratma published a study in Drug Safety titled “Effects of maternal epilepsy and antiepileptic drug use during pregnancy on perinatal health in offspring: nationwide, retrospective cohort study…
2003 – AEDs with valproate linked to neurological birth defects
By Jared Fink
In a 2003 edition of Epilepsia, a piece titled “Clinical care of pregnant women with epilepsy: neural tube defects and folic acid supplementation.” by M.S. Yerby and a team from North Pacific Epilepsy Research in Portland, Oregon…
2013 – Neurological and heart defects linked to Depakote
By Jared Fink
A piece by medical researchers led by F.J. Vajda published in Acta Neurol Scand. (October, 2013), titled “Associations between particular types of fetal malformation and antiepileptic drug exposure in utero.” lives up to its title and provides more…
2009 – More research links Depakote (and other AEDs) to birth defects
By Jared Fink
Appearing in the July-August, 2009 edition of the Spanish medical journal, Neurologia, a piece titled “Malformations and fetal death in the Spanish antiepileptic drug and pregnancy registry: results at 6 years” by M. Martinez Ferri et al. aimed…
2002 – Research shows AED exposure lifts rate of neonatal morbidity and birth defects
By Jared Fink
In April, 2002, a team of medical researchers from Aberdeen (UK) led by J.C. Dean published a study titled “Long term health and neurodevelopment in children exposed to antiepileptic drugs before birth.” in Journal of Medical Genetics investigating…
Depakote, other AEDs again linked to birth defects
By Jared Fink
An article appearing in the May, 2010 edition of Epilepsia titled “The teratogenic risk of antiepileptic drug polytherapy.” by F.J. Vajda and a team from Royal Melbourne Hospital and University of Melbourne (Australia) further explores the connection between…
2011 – Depacon, Depakene, Depakote exposure linked to poor language skills
By Jared Fink
In February, 2011, C. Nadebaum and a British research team published a piece in Neurology titled “Language skills of school-aged children prenatally exposed to antiepileptic drugs.” that provides important insight into the connection between antiepileptic drugs containing sodium…
1992 – Study links Depakote and birth defects
By Jared Fink
Back in 1992, a French research team led by C. Dravet published a piece in Neurology titled “Epilepsy, antiepileptic drugs, and malformations in children of women with epilepsy: a French prospective cohort study.” that illuminated risks of prenatal…